Cyclohexyl isocyanate → HCID 68125090, compound

HRID 2398175Notes

Reaction equation

[CH2:1]([N:3]1[CH2:9][CH:8]([C:10](=[O:13])[NH:11][CH3:12])[C:7]2[CH:14]=[CH:15][C:16]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:17][C:6]=2[CH2:5][CH2:4]1)[CH3:2].[CH:22]1([N:28]=[C:29]=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH2:1]([N:3]1[CH2:9][CH:8]([C:10](=[O:13])[NH:11][CH3:12])[C:7]2[CH:14]=[CH:15][C:16]([S:18]([NH:21][C:29]([NH:28][CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:30])(=[O:19])=[O:20])=[CH:17][C:6]=2[CH2:5][CH2:4]1)[CH3:2]

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 68124849HCID 68124849, compound

Product 1

HCID 68125090HCID 68125090, compound

Procedure

By the reaction of 3-ethylmethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide with cyclohexylisocyanate in a manner analogous to that described in Example 1, there is obtained 1-[(3-ethylmethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)sulfonyl]-3-cyclohexylurea. The starting material can be prepared by first reacting ethylmethylamine with phosgene to give ethylmethylcarbamoyl chloride and subsequently bringing the latter to reaction with 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide hydrochloride.

Sources & evidence

ORD record: ord-e8a2540a14b448f3b4e5e3fa0f173749
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

Loading…