2-Nitropropane → HCID 178457349, compound

Participants

Reaction Steps

Ten grams of 2-(4-nitrophenyl)-1,1-dimethyl-1-nitroethane, prepared from the reaction of p-nitrobenzyl chloride and 2-nitropropane catalyzed by lithium hydride, dissolved in dioxane, was hydrogenated in the presence of 0.8 grams of 10% ruthenium on carbon at 120° C. and 1600 p.s.i.g. for 7 hours. The reaction mixture was filtered and the filtrate was fractionally distilled to produce 6.7 grams of trans 2-(4-aminocyclohexyl)-1,1-dimethylethylamine (A) boiling point 78° C. at 0.2 mm Hg, and 1.5 grams of cis 2-(4-aminocyclohexyl)-1,1-dimethylethylamine (B), boiling point 69° C. at 0.2 mm Hg.

Provenance & Evidence