HCID 21434999, compound → HCID 178422963, compound

HRID 2398241Notes

Reaction equation

HRID 2398241 reaction equation
[CH:1]([O:3][CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH3:16])[N:14]=2)[C:9](=[O:17])[C:8]([C:18]([OH:20])=O)=[CH:7]1)=[O:2].[NH2:21][C:22]1[NH:26][N:25]=[N:24][N:23]=1>CN(C)C=O>[CH:1]([O:3][CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH3:16])[N:14]=2)[C:9](=[O:17])[C:8]([C:18]([NH:21][C:22]2[NH:26][N:25]=[N:24][N:23]=2)=[O:20])=[CH:7]1)=[O:2]

Participants

4

Reactant 2

HCID 21434999HCID 21434999, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178422963HCID 178422963, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1(2-formyloxyethyl)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (1.3 g) and N,N'-carbonyldiimidazole (0.8 g) in dimethylformamide (25 ml) were heated at 80° for 5 hours. 5-Amino-1H-tetrazole (0.45 g) was added and the mixture was stirred at 80° for 1 hour. The solid was collected and dried, m.p. 268.5°-269° (d), (40%).

Workup

  1. customThe solid was collected
  2. customdried

Sources & evidence

ORD record
ord-615d952070c043d3b9a92659c3f86595
Source dataset
uspto-grants-1977_05
Patent number
US04024255

Reaction notes

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