Glycine → L-Methionyl-L-valine

HRID 2398322Notes

Reaction equation

HRID 2398322 reaction equation
[NH2:1][CH:2]([C:7]([OH:9])=O)[CH2:3][CH2:4][S:5][CH3:6].NCC(O)=O.N[C@H](C(O)=O)CCSC.[NH2:24][C@H:25]([C:29]([OH:31])=[O:30])[CH:26]([CH3:28])[CH3:27]>O>[NH2:1][C@H:2]([C:7]([NH:24][C@H:25]([C:29]([OH:31])=[O:30])[CH:26]([CH3:28])[CH3:27])=[O:9])[CH2:3][CH2:4][S:5][CH3:6]

Participants

6

Reactant 4

HCID 750GlycineHCID 876(+-)-MethionineHCID 6137L-Methionine2×HCID 6287L-Valine2×

Product 1

HCID 7010520L-Methionyl-L-valine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure of Example 1A and B above by replacing DL-methionine and glycine respectively with L-methionine and L-valine (Aldrich Chemical Co., Beil 4,427). The title compound had a melting point of 227° to 229° C (d). The title compound was found to be water soluble. The product thus obtained was subjected to amino acid analysis and found to contain 49.44 mole percent valine and 50.56 mole percent methionine.

Workup

  1. customThe title compound was prepared
  2. customThe product thus obtained

Sources & evidence

ORD record
ord-05dc351208bb485da6bc199c65ae48f3
Source dataset
uspto-grants-1977_05
Patent number
US04024286

Reaction notes

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