1,3-Propanediamine → N-(3-aminopropyl)pyrimidin-2-amine

HRID 2398370Notes

Reaction equation

HRID 2398370 reaction equation

Br[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[O-]CC.[Na+]>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-Propanediamine

HCID 783452-Bromopyrimidine

HCID 2723922Sodium ethoxide

Product 1

HCID 14397405N-(3-aminopropyl)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 2-bromopyrimidine with 1,3-diaminopropane in ethanol containing sodium ethoxide gives 2-(3-aminopropylamino)pyrimidine.

Sources & evidence

ORD record: ord-8367b3aa41af45dfa7c2df9ff06c1332
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024271

Reaction notes

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