Diethylamine → HCID 21435271, compound

HRID 2398472Notes

Reaction equation

HRID 2398472 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:28]=[CH:27][C:9]([C:10]([C:12]2[O:13][C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])=[CH:8][CH:7]=1.[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>C(O)C>[CH2:29]([N:31]([CH2:32][CH3:33])[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:28]=[CH:27][C:9]([C:10]([C:12]2[O:13][C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])=[CH:8][CH:7]=1)[CH3:30]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 21435288HCID 21435288, compound

Product 1

HCID 21435271HCID 21435271, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[4-(3-Bromopropoxy)benzoyl]-3-phenylbenzofuran (2.5 g., 5.7 mmol.) is refluxed for 6 hours in 50 ml. of ethanol containing 20 ml. of diethylamine. The reaction mixture is concentrated under reduced pressure and the residue is dissolved in chloroform. The chloroform solution is washed with water, saturated aqueous sodium chloride solution and water, dried (MgSO4) and concentrated to give the title compound.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutionthe residue is dissolved in chloroform
  3. washThe chloroform solution is washed with water, saturated aqueous sodium chloride solution and water
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-c7cd80707f984a3f9c71c0eae9482ee5
Source dataset
uspto-grants-1977_05
Patent number
US04024273

Reaction notes

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