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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2398519Generated: October 30, 2026

Hydrochloric Acid → 4,6-Dibromo-5-hydroxypyridine-2-carboxylic acid

https://huagongshe.com/reaction/2398519

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 20674264HCID 20674264—
SolventWaterHCID 962—
Product4,6-Dibromo-5-hydroxypyridine-2-carboxylic acidHCID 2143296653%

Reaction Steps

A solution of 0.5 g sodium hydroxide in 15 ml of water was added to 2 g of 4,6-dibromo-5-hydroxy-2-pyridine-carboxylic acid methyl ester and refluxed for 2 hours. The product was isolated, by cooling and acidifying with concentrated hydrochloric acid, in 53% yield; m.p. 195° -197° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04025333
Source datasetuspto-grants-1977_05
ORD IDord-b806ab5a3fed4ab3871c1a73a4419a67
Source noteuspto-grants-1977_05