Hydrochloric Acid → 4,6-Dibromo-5-hydroxypyridine-2-carboxylic acid

HRID 2398519Notes

Reaction equation

HRID 2398519 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[CH:12]=[C:11]([Br:13])[C:10]([OH:14])=[C:9]([Br:15])[N:8]=1)=[O:6].Cl>O>[Br:13][C:11]1[C:10]([OH:14])=[C:9]([Br:15])[N:8]=[C:7]([C:5]([OH:6])=[O:4])[CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20674264HCID 20674264, compound

Product 1

HCID 214329664,6-Dibromo-5-hydroxypyridine-2-carboxylic acidYield 53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.5 g sodium hydroxide in 15 ml of water was added to 2 g of 4,6-dibromo-5-hydroxy-2-pyridine-carboxylic acid methyl ester and refluxed for 2 hours. The product was isolated, by cooling and acidifying with concentrated hydrochloric acid, in 53% yield; m.p. 195° -197° C.

Workup

  1. temperaturerefluxed for 2 hours
  2. customThe product was isolated
  3. temperatureby cooling

Sources & evidence

ORD record
ord-b806ab5a3fed4ab3871c1a73a4419a67
Source dataset
uspto-grants-1977_05
Patent number
US04025333

Reaction notes

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