Benzoyl chloride → HCID 54469111, compound

HRID 2398534Notes

Reaction equation

HRID 2398534 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([F:12])=[CH:4][C:3]=1[S:13]([NH2:16])(=[O:15])=[O:14].[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1C=CC=CC=1>[C:17]([NH:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:11])[F:10])[C:5]([F:12])=[CH:4][C:3]=1[S:13]([NH2:16])(=[O:14])=[O:15])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 21433222HCID 21433222, compound

Product 1

HCID 54469111HCID 54469111, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

6.5 g 2-amino-4-trifluoromethyl-5-fluoro-benzene sulfonamide are suspended in 150 ml dry benzene. 2.6 g benzoyl chloride are added to the vigorously stirred suspension, after which the reaction mixture is gently refluxed during 4 hours. The reaction mixture is then left aside overnight. The resulting white solid is then suction filtered and recrystallized from aqueous ethanol, to give 6.1 g 2-benzoylamino-4-trifluoromethyl-5-fluoro-benzene sulfonamide, m.p.= 223° C.

Workup

  1. temperatureafter which the reaction mixture is gently refluxed during 4 hours
  2. filtrationsuction filtered
  3. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-a7717482f04f4a318670ff42bc359254
Source dataset
uspto-grants-1977_05
Patent number
US04025508

Reaction notes

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