Hydrochloric Acid → HCID 86733246, compound

HRID 2398602Notes

Reaction equation

HRID 2398602 reaction equation
[ClH:1].[C:2]([CH2:6][CH2:7][C:8]([NH2:10])=[NH:9])([O:4]C)=[O:3].Cl>>[ClH:1].[C:8]([CH2:7][CH2:6][C:2]([OH:4])=[O:3])(=[NH:9])[NH2:10]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 1230032910567-33-6

Product 1

HCID 86733246HCID 86733246, compoundYield 99%

Procedure

A solution of 7.8 g. (0.047 mole) of β-carbomethoxypropionamidine hydrochloride in 217 ml. of 12N hydrochloric acid is heated at steam bath temperatures for one hour. The solution is cooled, evaporated in vacuo to dryness, and the residual product triturated several times with ethylene dichloride and filtered, 7.1 g. (99% yield), m.p. 138° -140° C. (McElvain, et al., J. Am. Chem. Soc., 71, 40 (1949) reports a melting point for crude product of 131° -137° C.).

Workup

  1. temperatureThe solution is cooled
  2. customevaporated in vacuo to dryness
  3. customthe residual product triturated several times with ethylene dichloride
  4. filtrationfiltered
  5. customfor crude product of 131° -137° C.

Sources & evidence

ORD record
ord-9955ba2c47f34b29a382966a0370d91a
Source dataset
uspto-grants-1977_05
Patent number
US04025504

Reaction notes

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