Hydrochloric Acid → HCID 86733246, compound

HRID 2398619Notes

Reaction equation

HRID 2398619 reaction equation
[ClH:1].[C:2]([CH2:6][CH2:7][C:8]([NH2:10])=[NH:9])([O:4]C)=[O:3].Cl>>[ClH:1].[C:8]([CH2:7][CH2:6][C:2]([OH:4])=[O:3])(=[NH:9])[NH2:10]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 1230032910567-33-6

Product 1

HCID 86733246HCID 86733246, compoundYield 99%

Procedure

A solution of 7.8 g. (0.047 mole) of β-carbomethoxypropionamidine hydrochloride in 217 ml. of 12N hydrochloric acid is heated at steam bath temperatures for one hour. The solution is cooled, evaporated in vacuo to dryness, and the residual product triturated several times with ethylene dichloride and filtered, 7.1 g. (99% yield), m.p. 138°-140° C. (McElvain, et al., J. Am. Chem. Soc., 71, 40 (1949) reports a melting point for crude product of 131°-137° C.).

Workup

  1. temperatureThe solution is cooled
  2. customevaporated in vacuo to dryness
  3. customthe residual product triturated several times with ethylene dichloride
  4. filtrationfiltered
  5. customfor crude product of 131°-137° C.

Sources & evidence

ORD record
ord-82de409b1609414e95bfc230b8d7414a
Source dataset
uspto-grants-1977_05
Patent number
US04025506

Reaction notes

Loading…