Hydrochloric Acid → HCID 21433856, compound

HRID 2398725Notes

Reaction equation

HRID 2398725 reaction equation
[CH3:1][NH:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][CH:5]=1.[Cl:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([C:23]([F:26])([F:25])[F:24])=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1.Cl>C(O)C>[ClH:12].[F:26][C:23]([F:24])([F:25])[C:19]1[CH:18]=[C:17]2[C:22]([C:13]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([C:3]([NH:2][CH3:1])=[O:11])=[CH:5][CH:6]=3)=[CH:14][CH:15]=[N:16]2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 676684-Chloro-7-(trifluoromethyl)quinolineHCID 2355164-Amino-N-methylbenzamide

Product 1

HCID 21433856HCID 21433856, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.1 mole of N-methyl-p-aminobenzamide, 0.1 mole of 4-chloro-7-trifluoromethylquinoline, 10 ml. of concentrated hydrochloric acid and 500 ml. of absolute ethanol is stirred at about 25° C. for 30 minutes. A precipitate begins to form, and the mixture is then heated at reflux for 4 hours. The mixture is cooled and filtered to obtain p-[(7-trifluoromethyl-4-quinolyl)amino]-N-methylbenzamide hydrochloride.

Workup

  1. customto form
  2. temperaturethe mixture is then heated
  3. temperatureat reflux for 4 hours
  4. temperatureThe mixture is cooled
  5. filtrationfiltered

Sources & evidence

ORD record
ord-96591702eadf41eda382282357447dfa
Source dataset
uspto-grants-1977_05
Patent number
US04025629

Reaction notes

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