Sodium Hydroxide → HCID 86734777, compound

HRID 2398745Notes

Reaction equation

HRID 2398745 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([CH:17]([O:22][CH3:23])[C:18]([O:20]C)=[O:19])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCOCC1.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([CH:17]([O:22][CH3:23])[C:18]([OH:20])=[O:19])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86734778HCID 86734778, compound

Product 1

HCID 86734777HCID 86734777, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Methyl 2-p-chlorophenyl-α-methoxy-6-benzoxazolyl-acetate (4.0 g.) was dissolved in dioxan (50 ml.) and a solution of sodium hydroxide (0.7g) in water was added. The solution was stirred for three hours then evaporated to dryness. The residue was stirred with dilute hydrochloric acid for thirty minutes. The solid was filtered off and recrystallised from water-ethanol to give 2-p-chlorophenyl-α-methoxy-6-benzoxazolylacetic acid, m.pt. 164°-6° C.

Workup

  1. customthen evaporated to dryness
  2. stirringThe residue was stirred with dilute hydrochloric acid for thirty minutes
  3. filtrationThe solid was filtered off
  4. customrecrystallised from water-ethanol

Sources & evidence

ORD record
ord-c75df9b7545d460ba972a0fa0b25dc9a
Source dataset
uspto-grants-1977_05
Patent number
US04025636

Reaction notes

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