Hydrofluoric Acid → HCID 12251281, compound

HRID 2398804Notes

Reaction equation

HRID 2398804 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1CCC(O)=O.F>>[C:5]12([CH2:4][CH2:3][C:2](=[O:1])[CH2:7][CH2:6]1)[C:8]1[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2](=[O:1])[CH2:3][CH2:4]2

Participants

3

Reactant 2

HCID 14917Hydrofluoric AcidHCID 21433513HCID 21433513, compound

Product 1

HCID 12251281HCID 12251281, compound

Procedure

A 4-oxo-1-phenylcyclohexane-3-propionic acid (i) prepared in step (6) or (6') is cyclized, e.g., by allowing it to stand at room temperature for from about 15 to about 80 hours with liquid hydrogen fluoride, to yield a corresponding spiro[cyclohexane-1,1'(2'H)-naphthalene]-4,4'(3'H)-dione (o).

Sources & evidence

ORD record
ord-89d6d007624c40d48479759c2248f6d2
Source dataset
uspto-grants-1977_05
Patent number
US04025558

Reaction notes

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