Hydrogen Peroxide → HCID 21434136, compound

HRID 2398823Notes

Reaction equation

HRID 2398823 reaction equation
[OH:1]O.[F:3][C:4]([F:37])([F:36])[C:5]1[CH:27]=[C:26]([S:28][C:29]2[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:6]=1[NH:7][C:8](=[O:23])[C:9]1[C:10](=[C:12]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:13]=[C:14]([C:17]#[N:18])[C:15]=1[CH3:16])[OH:11].O>C(O)(=O)C>[F:37][C:4]([F:36])([F:3])[C:5]1[CH:27]=[C:26]([S:28]([C:29]2[CH:30]=[CH:31][C:32]([Br:35])=[CH:33][CH:34]=2)=[O:1])[CH:25]=[CH:24][C:6]=1[NH:7][C:8](=[O:23])[C:9]1[C:10](=[C:12]([C:19]([CH3:21])([CH3:22])[CH3:20])[CH:13]=[C:14]([C:17]#[N:18])[C:15]=1[CH3:16])[OH:11]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 21434108HCID 21434108, compound

Product 1

HCID 21434136HCID 21434136, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

30% w/v Aqueous hydrogen peroxide solution (70 μl.) is added to a suspension of 2'-trifluoromethyl-4'-(4-bromophenylthio)-5-cyano-3-t-butyl-6-methylsalicylanilide (0.25 g.) in acetic acid (4 ml.), and the mixture heated at 70°-80° C. for 1 hour. Water (2 ml.) is then added and the solution is cooled slowly to room temperature. The crystalline solid which is thus obtained is separated by filtration and dried to give 2'-trifluoromethyl-4'-(4-bromophenylsulphinyl)-5-cyano-3-t-butyl-6-methylsalicylanilide, m.p. 178°-180° C.

Workup

  1. temperaturethe mixture heated at 70°-80° C. for 1 hour
  2. customThe crystalline solid which is thus obtained
  3. customis separated by filtration
  4. customdried

Sources & evidence

ORD record
ord-9a34162ae07c48259c6972916edbaa65
Source dataset
uspto-grants-1977_05
Patent number
US04025647

Reaction notes

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