Hydrochloric Acid → [N-(2,6-dimethylphenyl)-N-methylcarbamimidoyl]urea

HRID 2398832Notes

Reaction equation

HRID 2398832 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[N:9]([CH3:20])[C:10]([NH:12][C:13]([NH:15]C(C)(C)C)=[O:14])=[NH:11].Cl>>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[N:9]([CH3:20])[C:10]([NH:12][C:13]([NH2:15])=[O:14])=[NH:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 1403273821-tert-butyl-3-[N-(2,6-dimethylphenyl)-N-methylcarbamimidoyl]urea

Product 1

HCID 140335550[N-(2,6-dimethylphenyl)-N-methylcarbamimidoyl]urea

Procedure

A mixture of 27 g. (0.106 mole) of 1-(2,6-dimethylphenyl-N-methylamidino)-3-(t-butyl)urea and 200 ml. of conc. hydrochloric acid is refluxed for 1/2 hour. The reaction mixture is cooled, the precipitated solid filtered and washed with 10 ml. of 1:1 HCl/H2O and dried. The product is then recrystallized from ethanol-ether to obtain 1-(2,6-dimethylphenyl-N-methylamidino)urea.

Workup

  1. additionA mixture of 27 g
  2. temperatureThe reaction mixture is cooled
  3. filtrationthe precipitated solid filtered
  4. washwashed with 10 ml
  5. dry with materialof 1:1 HCl/H2O and dried
  6. customThe product is then recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-b7566556f8dc4bf39a710a91a439e651
Source dataset
uspto-grants-1977_05
Patent number
US04025652

Reaction notes

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