Hydrochloric Acid → 5-(Piperidin-1-yl)pentanoic acid hydrochloride

HRID 2398863Notes

Reaction equation

HRID 2398863 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:15]>O>[ClH:15].[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20361138HCID 20361138, compound

Product 1

HCID 545927615-(Piperidin-1-yl)pentanoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

23.5 g. (0.117 mole) of methyl δ-piperidinovalerate is dissolved in a combination of 125 ml. of concentrated hydrochloric acid and 125 ml. of water and refluxed with stirring for 16 hours. The excess water is removed using reduced pressure (water aspirator) to give a semi-solid residue which is triturated with acetone, filtered and dried. 21.0 g. (79%) of colorless crystals of δ-piperidinovaleric acid hydrochloride are obtained, m.p. of 202°-204° C.

Workup

  1. customThe excess water is removed
  2. customto give a semi-solid residue which
  3. customis triturated with acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-ef913b63a5674fbfbe351400c02d407d
Source dataset
uspto-grants-1977_05
Patent number
US04025630

Reaction notes

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