Hydrochloric Acid → HCID 21433934, compound

HRID 2398911Notes

Reaction equation

HRID 2398911 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[C:9](=O)[CH2:8][S:7][CH2:6]1)=[O:4].[CH3:11][CH:12]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH:13]([C:15]1[CH:16]=C(O)[CH:18]=[C:19]([CH:21]=1)[OH:20])[CH3:14].Cl>C(O)C>[OH:20][C:19]1[C:18]2[C:9]3[CH2:8][S:7][CH2:6][C:5]=3[C:3](=[O:4])[O:2][C:1]=2[CH:16]=[C:15]([CH:13]([CH:12]([CH3:11])[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:14])[CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 2581765-(3-Methyloctan-2-yl)benzene-1,3-diol

Product 1

HCID 21433934HCID 21433934, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 20 g. (0.125 mole) of methyl-4-oxo-2,3,4,5-tetrahydrothiophene-3-carboxylate and 32 g. (0.135 mole) of 5-(3-methyl-2-octyl)resorcinol in 200 ml. of absolute ethanol was cooled in an ice-salt bath and saturated with anhydrous hydrogen chloride. The reaction mixture was allowed to stand at room temperature for 72 hours and the solid which formed was removed by filtration. Recrystallization from ethanol gave 16 g. (37%) m.p. 165°-166°. The structure was confirmed by the IR and nmr spectra.

Workup

  1. customthe solid which formed
  2. customwas removed by filtration
  3. customRecrystallization from ethanol
  4. customgave 16 g

Sources & evidence

ORD record
ord-35396c107ca540f380daeda5bfcbf8ec
Source dataset
uspto-grants-1977_05
Patent number
US04025630

Reaction notes

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