Trimethyl Phosphate → 7H-Pyrrolo[3,2-g]quinolin-7-one, 1,2,3,8-tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-

HRID 2398942Notes

Reaction equation

[O:1]=[C:2]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][C:6]3[N:18]([CH3:19])[CH:17]([CH3:20])[C:16]([CH3:22])([CH3:21])[C:7]=3[CH:8]=2)[NH:3]1.P(OC)(OC)(O[CH3:26])=O>>[O:1]=[C:2]1[CH:11]=[C:10]([C:12]([F:13])([F:14])[F:15])[C:9]2[C:4](=[CH:5][C:6]3[N:18]([CH3:19])[CH:17]([CH3:20])[C:16]([CH3:21])([CH3:22])[C:7]=3[CH:8]=2)[N:3]1[CH3:26]

Participants

Reactant 2

HCID 10541Trimethyl Phosphate

HCID 323233NSC282112

Product 1

HCID 938867H-Pyrrolo[3,2-g]quinolin-7-one, 1,2,3,8-tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-

Procedure

refluxing said 7-oxo-1,2,3,3-tetramethyl-5-trifluoromethyl-2,3,7,8-tetrahydro-1H-pyrrolo [3,2-g] quinoline with trimethyl phosphate to yield 7-oxo-1,2,3,3,8-pentamethyl-5-trifluoromethyl-2,3,7,8-tetrahydro-1H-pyrrolo [3,2-g] quinoline.

Workup

temperaturerefluxing

Sources & evidence

ORD record: ord-110aafcee05244178bc4f32f62c00024
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04026898

Reaction notes

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