Chloride → p-Chloromethylphenylacetyl chloride

HRID 2398953Notes

Reaction equation

HRID 2398953 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.S(Cl)([Cl:15])=O.[Cl-]>>[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([Cl:15])=[O:12])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 312ChlorideHCID 24386Thionyl ChlorideHCID 103134194-(Chloromethyl)phenylacetic acid

Product 1

HCID 20380233p-Chloromethylphenylacetyl chloride

Procedure

A mixture of 1 g of p-chloromethylphenylacetic acid and 6 ml of thionylchloride is stirred at room temperature for 25 hours after which the excessthionyl chloride is removed under vacuum to yield p-chloromethylphenylacetyl chloride.

Workup

  1. customis removed under vacuum

Sources & evidence

ORD record
ord-514b7f7ee8be4c2ca3d1f24d82205815
Source dataset
uspto-grants-1977_05
Patent number
US04026887

Reaction notes

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