Hydrogen Peroxide → HCID 131710803, compound

HRID 2398974Notes

Reaction equation

HRID 2398974 reaction equation
[CH2:1]([N:3]([CH2:24][CH3:25])[CH2:4][CH2:5][N:6]1[C:14]2[CH:13]=[CH:12][C:11]([CH2:15][OH:16])=[C:10]3[S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:8]([C:9]=23)=[N:7]1)[CH3:2].[OH:26]O>CC(C)=O>[CH2:24]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:14]2[CH:13]=[CH:12][C:11]([CH2:15][OH:16])=[C:10]3[S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[C:8]([C:9]=23)=[N+:7]1[O-:26])[CH3:25]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 322482H-(1)Benzothiopyrano(4,3,2-cd)indazole-5-methanol, 2-(2-(diethylamino)ethyl)-

Product 1

HCID 131710803HCID 131710803, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 2-(2-(diethylamino)ethyl)-2H(1)benzothiopyrano[4,3,2-cd]indazole-5-methanol (0.18 g.) in acetone (3 ml.) was added 30% aqueous hydrogen peroxide (0.21 ml.) and the mixture left overnight at room temperature. Evaporation under reduced pressure and crystallization from ethanol-ethyl acetate gave 2-(2-(diethylamino)ethyl)-2H(1)benzothiopyrano[4,3,2-cd]indazole-5-methanol N-oxide one-third hydrate which melted at 142°-143° (decomp.).

Workup

  1. customEvaporation
  2. customunder reduced pressure and crystallization from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-e21710da07ed47a69e99d2416feb7165
Source dataset
uspto-grants-1977_05
Patent number
US04026899

Reaction notes

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