Hydrogen Peroxide → HCID 131710332, compound

HRID 2398976Notes

Reaction equation

HRID 2398976 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[C:16]4[C:15]([S:17][C:4]=2[CH:3]=1)=[C:14]([CH3:18])[CH:13]=[CH:12][C:11]=4[N:10]([CH2:19][CH2:20][N:21]([CH:23]([CH3:25])[CH3:24])[CH3:22])[N:9]=3.[OH:26]O>CC(C)=O>[OH2:26].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[C:16]4[C:15]([S:17][C:4]=2[CH:3]=1)=[C:14]([CH3:18])[CH:13]=[CH:12][C:11]=4[N:10]([CH2:19][CH2:20][N:21]([CH:23]([CH3:25])[CH3:24])[CH3:22])[N+:9]=3[O-:26]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 21432224HCID 21432224, compound

Product 1

HCID 131710332HCID 131710332, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 8-chloro-2-(2-(isopropylmethylamino)ethyl)-5-methyl-2H(1)benzothiopyrano[4,3,2-cd]indazole (0.19 g.) in acetone (3 ml.) was added 0.25 ml. of 30% aqueous hydrogen peroxide and the mixture was kept at room temperature for 4 days. The solid obtained on evaporation of the solution under reduced pressure was crystallized from ethanol-ether to give 8-chloro-2-(2 -(isopropylmethylamino)ethyl)-5-methyl-2H(1)benzothiopyrano[4,3,2-cd]indazole N-oxide monohydrate, m.p. 132°-133° (decomp.).

Workup

  1. customThe solid obtained on evaporation of the solution under reduced pressure
  2. customwas crystallized from ethanol-ether

Sources & evidence

ORD record
ord-92a6d6cfd5e74d28a277d915afc8d603
Source dataset
uspto-grants-1977_05
Patent number
US04026899

Reaction notes

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