Thiosemicarbazide → 1-(1-Methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide

HRID 2398999Notes

Reaction equation

HRID 2398999 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10](Cl)=[O:11].[NH2:13][NH:14][C:15]([NH2:17])=[S:16]>O1CCCC1>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]([NH:13][NH:14][C:15]([NH2:17])=[S:16])=[O:11]

Participants

4

Reactant 2

HCID 2723789ThiosemicarbazideHCID 109870491-Methyl-5-nitro-2-imidazolecarboxylic acid chloride

Product 1

HCID 214322521-(1-Methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 1-methyl-5-nitro-2-imidazolecarboxylic acid chloride (1.1 g.) in 25 ml. of dry tetrahydrofuran is added 0.55 g. powdered thiosemicarbazide and the mixture is stirred at room temperature for 24 hours. The reaction mixture is evaporated to dryness and water is added. The solution is made basic with sodium hydroxide and the solid is filtered, washed with water and dried affording 1-(1-methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide.

Workup

  1. customThe reaction mixture is evaporated to dryness and water
  2. additionis added
  3. filtrationthe solid is filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-9666a97a95734b01b73d32dae1d697a8
Source dataset
uspto-grants-1977_05
Patent number
US04026903

Reaction notes

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