Thiosemicarbazide → HCID 178481319, compound

HRID 2399005Notes

Reaction equation

HRID 2399005 reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10](=[NH:14])OCC.[NH2:15][NH:16][C:17]([NH2:19])=[S:18]>OS(O)(=O)=O.CO>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]([NH:15][NH:16][C:17]([NH2:19])=[S:18])=[NH:14]

Participants

5

Reactant 2

HCID 2723789ThiosemicarbazideHCID 21432269Ethyl 1-methyl-5-nitro-1H-imidazole-2-carboximidate

Product 1

HCID 178481319HCID 178481319, compound

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolvent

Procedure

To a stirred mixture of ethyl 1-methyl-5-nitro-2-imidazolecarboximidate (0.198 g., 0.001 mole) and thiosemicarbazide (0.091 g., 0.001 mole) in 5 ml. of methanol is added 1 drop of conc. H2SO4 and the mixture is stirred at room temperature for 50 minutes. The solid is filtered and washed with methanol, yielding 0.149 g. of the title compound, melting point 200°-201° C. dec.

Workup

  1. filtrationThe solid is filtered
  2. washwashed with methanol
  3. customyielding 0.149 g

Sources & evidence

ORD record
ord-f8c6d7817d5a4d9a905674142f54b989
Source dataset
uspto-grants-1977_05
Patent number
US04026903

Reaction notes

Loading…