HCID 21432595, compound → HCID 21432594, compound

HRID 2399040Notes

Reaction equation

HRID 2399040 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][C:16]=1[NH2:17])[C:7]([C:9]1[S:10][CH:11]=[CH:12][N:13]=1)=[O:8])([O-])=O.[H][H]>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][C:16]=1[NH2:17])[C:7]([C:9]1[S:10][CH:11]=[CH:12][N:13]=1)=[O:8]

Participants

5

Reactant 2

HCID 21432595HCID 21432595, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21432594HCID 21432594, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 20 g. (0.082 mol) of 2-(3-nitro-4-aminobenzoyl)thiazole in 1 liter of tetrahydrofuran containing 5 g. of 5% palladium on carbon was reduced with hydrogen under a pressure of 3 atmospheres. The resulting mixture was filtered and concentrated in vacuo to yield 2-(3,4-diaminobenzoyl) thiazole as unstable red needles, mp. 125°-127° C. (dec.) (acetone-water).

Workup

  1. additionA suspension of 20 g
  2. filtrationThe resulting mixture was filtered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ed02df11ae024bf8b8db27b90692a5cb
Source dataset
uspto-grants-1977_05
Patent number
US04026936

Reaction notes

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