Methyl Isocyanate → HCID 13498706, compound

HRID 2399118Notes

Reaction equation

HRID 2399118 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1.[CH3:12][N:13]=[C:14]=[O:15]>C(#N)C>[CH3:12][NH:13][C:14]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)=[O:15]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 128894012-((2-Aminoethyl)thiomethyl)pyridine

Product 1

HCID 13498706HCID 13498706, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-[(2-aminoethyl)thiomethyl]pyridine (7.0 g.) and methyl isocyanate (2.7 g.) in acetonitrile was heated for 18 hours in a pressure vessel at 100°. After cooling, the solid obtained was collected and recrystallised from acetonitrile/ether to give N-methyl-N'-[2-(2-pyridylmethylthio)ethyl]urea m.p. 63°-66°.

Workup

  1. temperaturewas heated for 18 hours in a pressure vessel at 100°
  2. temperatureAfter cooling
  3. customthe solid obtained
  4. customwas collected
  5. customrecrystallised from acetonitrile/ether

Sources & evidence

ORD record
ord-b26e5ea485314a2c933f0e9b11792995
Source dataset
uspto-grants-1977_05
Patent number
US04027026

Reaction notes

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