Triphenyl(propyl)phosphonium iodide → 4-Fluoro-3'-(butenyl)-2'-methyl-benzophenone

HRID 2399131Notes

Reaction equation

HRID 2399131 reaction equation
[CH3:1][C:2]1[C:9]([C:10](=[O:18])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[I-].[CH2:20]([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:21][CH3:22]>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]([C:9]2[CH:8]=[CH:7][CH:6]=[C:3]([CH:4]=[CH:20][CH2:21][CH3:22])[C:2]=2[CH3:1])=[O:18])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 10982905Triphenyl(propyl)phosphonium iodideHCID 214328952-Methyl-3-(p-fluorobenzoyl)-benzaldehyde

Product 1

HCID 538010194-Fluoro-3'-(butenyl)-2'-methyl-benzophenone

Procedure

Using the procedure of Examples 1 and 2, 2-methyl-3-(p-fluorobenzoyl)-benzaldehyde and n-propyl-triphenyl phosphonium iodide were reacted to obtain 4-fluoro-3'-(butenyl)-2'-methyl-benzophenone which was hydrogenated to form 4-fluoro-3'-(n-butyl)-2'-methyl-benzophenone in the form of an oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-00bfbadc6bf24c76b22708903d711d72
Source dataset
uspto-grants-1977_05
Patent number
US04027040

Reaction notes

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