HCID 21333222, compound → HCID 21333289, compound

HRID 2399162Notes

Reaction equation

HRID 2399162 reaction equation
C([N:8]([CH2:21][CH:22]([OH:33])[CH2:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[O:31][CH3:32])[CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=[O:20])[NH2:19])=[CH:14][N:13]=1)C1C=CC=CC=1>C(O)C>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([O:11][CH2:10][CH2:9][NH:8][CH2:21][CH:22]([OH:33])[CH2:23][O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[O:31][CH3:32])=[N:13][CH:14]=1)(=[O:20])[NH2:19]

Participants

3

Reactant 1

HCID 21333222HCID 21333222, compound

Product 1

HCID 21333289HCID 21333289, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 17.3 g of 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-ethyl]-amino]-3-(2-methoxy-phenoxy)-2-propanol in 180 ml of ethanol is hydrogenated analogously to Example 1, giving 1-[2-(5-carbamoyl-2-pyridyloxy)-ethylamino]-3-(2-methoxy-phenoxy)-2-propanol, which melts at 132°-133° C. after crystallisation from ethanol. It forms a neutral fumarate as a hemihydrate which melts at 98°-105° C. after crystallisation from methanol.

Sources & evidence

ORD record
ord-7d163aa3483a492ba5c7b8e2b401151c
Source dataset
uspto-grants-1977_05
Patent number
US04027027

Reaction notes

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