HCID 21333222, compound → HCID 21333289, compound

Participants

Reaction Steps

A solution of 17.3 g of 1-[N-benzyl-N-[2-(5-carbamoyl-2-pyridyloxy)-ethyl]-amino]-3-(2-methoxy-phenoxy)-2-propanol in 180 ml of ethanol is hydrogenated analogously to Example 1, giving 1-[2-(5-carbamoyl-2-pyridyloxy)-ethylamino]-3-(2-methoxy-phenoxy)-2-propanol, which melts at 132°-133° C. after crystallisation from ethanol. It forms a neutral fumarate as a hemihydrate which melts at 98°-105° C. after crystallisation from methanol.

Provenance & Evidence