Oxalyl chloride → HCID 20310400, 화합물

HRID 2399169노트

반응식

HRID 2399169 반응식
[Na+].O1C=CCCC1C([O-])=O.O1CCCCC1C(O)=O.C(Cl)(=O)C(Cl)=O.C(N1CCNCC1)C1C=CC=CC=1.[CH2:39]([N:46]1[CH2:51][CH2:50][N:49]([C:52]([CH:54]2[CH2:59][CH2:58][CH2:57][CH2:56][O:55]2)=[O:53])[CH2:48][CH2:47]1)C1C=CC=CC=1.O1CCCCC1C(N1CCNCC1)=O.[NH2:74][C:75]1[C:84]2[C:79](=[CH:80][C:81]([O:87][CH3:88])=[C:82]([O:85][CH3:86])[CH:83]=2)[N:78]=C(Cl)[N:76]=1>>[O:55]1[CH2:56][CH2:57][CH2:58][CH2:59][CH:54]1[C:52]([N:49]1[CH2:48][CH2:47][N:46]([C:39]2[N:74]=[C:75]([NH2:76])[C:84]3[C:79](=[CH:80][C:81]([O:87][CH3:88])=[C:82]([O:85][CH3:86])[CH:83]=3)[N:78]=2)[CH2:51][CH2:50]1)=[O:53]

참가 물질

8

반응물 7

HCID 65578Oxalyl chlorideHCID 759941-BenzylpiperazineHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 10964532Oxane-2-carboxylic acidHCID 20310402N-benzyl-N'-(tetrahydropyran-2-carbonyl)piperazineHCID 20385082(Oxan-2-yl)(piperazin-1-yl)methanoneHCID 236651632H-Pyran-2-carboxylic acid, 3,4-dihydro-, sodium salt (1:1)

생성물 1

HCID 20310400HCID 20310400, 화합물

실험 절차

To prepare the compound of formula III, the 3,4-dihydro-2H-pyran-2 carboxylic acid sodium salt is hydrogenated to the tetrahydro-pyran-2-carboxylic acid. This compound converted to the acid chloride with oxalyl chloride and is then treated with N-benzyl piperazine. The resultant N-benzyl-N'-(tetrahydropyran-2-carbonyl)piperazine is hydrogenated to giveN-(tetrahydro-pyran-2-carbonyl)piperazine. This compound is reacted with the known compound 4-amino-2-chloro-6,7-dimethoxyquinazoline to give the active drug 2-[ 4-(tetrahydro-pyran-2-carbonyl)piperazinyl]-4-amino-6,7-dimethoxyquinazoline.

출처 및 근거

ORD 기록
ord-aa4a700664d14bbda07ece18d0d20a83
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04026894

반응 노트

불러오는 중…