3-Benzyloxy-phenylboronic acid → HCID 19386221, compound

HRID 2399202Notes

Reaction equation

HRID 2399202 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:10][CH:9]=2)=[N:6][CH:7]=1.[CH2:23]([O:30][C:31]1[CH:32]=[C:33](B(O)O)[CH:34]=[CH:35][CH:36]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([O:30][C:31]1[CH:36]=[C:35]([C:2]2[CH:3]=[N:4][C:5]([C:8]3[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:10][CH:9]=3)=[N:6][CH:7]=2)[CH:34]=[CH:33][CH:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27343133-Benzyloxy-phenylboronic acidHCID 19050464HCID 19050464, compound

Product 1

HCID 19386221HCID 19386221, compound

Procedure

5-Bromo-2-(4-octyloxyphenyl)pyrimidine and 3-benzyloxybenzeneboronic acid are reacted analogously to Example 1 to give 5-(3-benzyloxyphenyl)-2-(4-octyloxyphenyl)pyrimidine. ##STR35## Removal of the benzyl protecting group from 5-(3-benzyloxyphenyl)-2-(4-octyloxyphenyl) pyrimidine by hydrogenation analogously to Example i gives 5-(3-hydroxyphenyl)-2-(4-octyloxyphenyl) pyrimidine. ##STR36##

Sources & evidence

ORD record
ord-aaedd29859814bdda4e27c3bd42e26b6
Source dataset
uspto-grants-1995_09
Patent number
US05447656

Reaction notes

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