Hydrochloric Acid → HCID 19386980, compound

HRID 2399333Notes

Reaction equation

HRID 2399333 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH2:15][NH:16][CH2:17][CH2:18][OH:19])=[C:9]([N:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]3=[O:26])[C:8]=2[CH:27]=1)([O-:3])=[O:2].[ClH:28]>C(OCC)C>[ClH:28].[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C:11]([CH3:13])([CH3:14])[C:10]([CH2:15][NH:16][CH2:17][CH2:18][OH:19])=[C:9]([N:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]3=[O:26])[C:8]=2[CH:27]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19386981HCID 19386981, compound

Product 1

HCID 19386980HCID 19386980, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 6-nitro-2,2-dimethyl-3-(2-hydroxyethylamino)methyl-4-(2-oxo-1,2-dihydropyridin-1-yl)-2H-1-benzopyran (0.44 g, 1.18 mmol) in diethylether was treated with excess ethanolic hydrochloric acid (2M) and the resulting precipitate isolated by filtration, to give 0.36 g of 6-nitro-2,2-dimethyl-3-(2-hydroxyethylamino)methyl-4-(2-oxo-1,2-dihydropyridin-1-yl)-2H-1-benzopyran hydrochloride, m.p. 225° C.

Workup

  1. customthe resulting precipitate isolated by filtration

Sources & evidence

ORD record
ord-2598dcfbba44460bb6172dddc3be322b
Source dataset
uspto-grants-1995_09
Patent number
US05447943

Reaction notes

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