Potassium Carbonate → HCID 19385488, compound

HRID 2399356Notes

Reaction equation

HRID 2399356 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH:15]([F:17])[F:16])=[C:10]([O:18][CH3:19])[CH:9]=2)=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>C(N)C1C=CC=CC=1>[CH2:5]([NH:4][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH:15]([F:17])[F:16])=[C:10]([O:18][CH3:19])[CH:9]=2)=[CH:6][CH:7]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19385498HCID 19385498, compound

Product 1

HCID 19385488HCID 19385488, compoundYield 158%

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Procedure

5 g (17 mmol) of 3-chloro-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine are heated in 30 ml of benzylamine at 180° C. for 1 hour. The mixture is stirred into 500 ml of saturated potassium carbonate solution, and the resulting precipitate is filtered off with suction, washed thoroughly with water, dried and recrystallized from ethyl acetate. 4.8 g (77.4%) of 3-benzylamino-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine of m.p. 136° C. are obtained.

Workup

  1. filtrationthe resulting precipitate is filtered off with suction
  2. washwashed thoroughly with water
  3. customdried
  4. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-244bc343fd5248e8bc77fcb953a23f7f
Source dataset
uspto-grants-1995_09
Patent number
US05449676

Reaction notes

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