Hydrazine hydrate (1:1) → HCID 19385492, compound

HRID 2399357Notes

Reaction equation

HRID 2399357 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH:17]([CH3:19])[CH3:18])[CH:9]=2)=[CH:6][CH:7]=1.O.[NH2:21][NH2:22]>C(O)CCC>[NH:21]([C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH:17]([CH3:19])[CH3:18])[CH:9]=2)=[CH:6][CH:7]=1)[NH2:22]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19385502HCID 19385502, compound

Product 1

HCID 19385492HCID 19385492, compoundYield 76.8%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

25 g (90 mmol) of 3-chloro-6-[4-methoxy-3-(1-methylethoxy)phenyl]pyridazine are boiled under reflux with 22.5 g (0.45 mol) of hydrazine hydrate in 200 ml of butanol for 12 hours. The reaction mixture is subsequently diluted to three to four times the volume with ice-water, and the precipitate is filtered off and recrystallized from isopropanol/cyclohexane. 18.9 g (76.8%) of 3-hydrazino-6-[4-methoxy-3-(1-methylethoxy)phenyl]pyridazine of m.p. 116° C. are obtained.

Workup

  1. filtrationthe precipitate is filtered off
  2. customrecrystallized from isopropanol/cyclohexane

Sources & evidence

ORD record
ord-8017215211154ca19ad697f2f5d0eda8
Source dataset
uspto-grants-1995_09
Patent number
US05449676

Reaction notes

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