Water → HCID 19385493, compound

Participants

Reaction Conditions

Reaction Steps

20.0 g (69.8 mmol) of 3-chloro-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine are boiled under reflux in 100 ml of n-butanol with 17 ml (350 mmol) of hydrazine hydrate for 8 hours. The solution is cooled to about 80° C. and stirred with 100 ml of saturated sodium carbonate solution and 200 ml of water. The precipitate is filtered off with suction, washed with water and dried in vacuo. 18.4 g (93.4%) of 3-hydrazino-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine of m.p. 154° C. are obtained.

Provenance & Evidence