Water → HCID 19385493, compound

HRID 2399359Notes

Reaction equation

HRID 2399359 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH:15]([F:17])[F:16])=[C:10]([O:18][CH3:19])[CH:9]=2)=[CH:6][CH:7]=1.O.[NH2:21][NH2:22].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)CCC>[NH:21]([C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH:15]([F:17])[F:16])=[C:10]([O:18][CH3:19])[CH:9]=2)=[CH:6][CH:7]=1)[NH2:22]

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 24654Hydrazine hydrate (1:1)HCID 19385498HCID 19385498, compound

Product 1

HCID 19385493HCID 19385493, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
80 °C

Procedure

20.0 g (69.8 mmol) of 3-chloro-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine are boiled under reflux in 100 ml of n-butanol with 17 ml (350 mmol) of hydrazine hydrate for 8 hours. The solution is cooled to about 80° C. and stirred with 100 ml of saturated sodium carbonate solution and 200 ml of water. The precipitate is filtered off with suction, washed with water and dried in vacuo. 18.4 g (93.4%) of 3-hydrazino-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine of m.p. 154° C. are obtained.

Workup

  1. filtrationThe precipitate is filtered off with suction
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-3a0cba3dc25e48ddba83b3131acb859d
Source dataset
uspto-grants-1995_09
Patent number
US05449676

Reaction notes

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