反应详情

A mixture of 4-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethynylcyclohexan-1-one dimethyl ketal (0.13 g, 0.36 mmol) and p-toluenesulfonic acid (catalytic amount) in acetone (5 mL) was stirred under an argon atmosphere at room temperature for 1.5 h. The mixture was concentrated, diluted with ethyl acetate and washed with water. The organic extract was dried (magnesium sulfate) and the solvent was removed in vacuo to provide an oil (0.11 g, 97%).

1. concentrationThe mixture was concentrated
2. additiondiluted with ethyl acetate
3. washwashed with water
4. extractionThe organic extract
5. dry with materialwas dried (magnesium sulfate)
6. customthe solvent was removed in vacuo