N-bromobutanimide → Methyl 2-(4-bromomethylphenoxy)-2-(2-chlorophenyl)acetate

HRID 2399451Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([O:13][C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)[C:9]([O:11][CH3:12])=[O:10].C1C(=O)N([Br:28])C(=O)C1>>[Br:28][CH2:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:9]([O:11][CH3:12])=[O:10])=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 19385716Methyl 2-(2-chlorophenyl)-2-(4-methylphenoxy)acetate

Product 1

HCID 19385740Methyl 2-(4-bromomethylphenoxy)-2-(2-chlorophenyl)acetateYield 76.2%

Procedure

The product of Step B (0.200 g, 0.69 mmol) was brominated with NBS (117 mg, 0.66 mmol) and purified using the procedure described in Step C of Example 3, and afforded 0.186 g (73%) of the title compound.

Workup

custompurified

Sources & evidence

ORD record: ord-4b3981749b9041e2ac3994ef7de350c5
Source dataset: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05449682

Reaction notes

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