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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2399554Generated: October 29, 2026

Formamide → Benzamide

https://huagongshe.com/reaction/2399554

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormamideHCID 713—
ReactantHydrogen CyanideHCID 768—
ReactantBenzonitrileHCID 7505—
ProductBenzamideHCID 2331—

Reaction Steps

A solution of formamide (0.5047 g, 11.2 retool), PdBr2 (0.165 g, 0.62 mmol) in 25 mL of benzonitrile was stirred at reflux for 16 hours. At the end of this time, it was found that 0.29 mmol of HCN was produced. Benzamide was also produced.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05449808
Source datasetuspto-grants-1995_09
ORD IDord-c5df8d28ede348ce9b8f71a8b997fa1f
Source noteuspto-grants-1995_09