反应详情

A solution of aqueous 1N NaOH (10.00 ml) is added to a stirred solution of methyl 6-chloro-3-methyl-pyridine-2-carboxylate (1.0 g, 5.39 mmoles) in THF:MeOH (10 ml:2 ml). The mixture is stirred at room temperature for 3 hours. The organic solvent is removed under reduced pressure and the semi-solid is dissolved in water and acidified to pH 1-2 with aqueous 1N HCl. The resulting precipitate is filtered, washed with water, and dried at 40° C. in vacuum oven for 12 hours to give the title compound as a white solid (780 mg, 84%). Mass spectrum (m/z): 172.0 (M+1).

1. customThe organic solvent is removed under reduced pressure
2. dissolutionthe semi-solid is dissolved in water
3. filtrationThe resulting precipitate is filtered
4. washwashed with water
5. customdried at 40° C. in vacuum oven for 12 hours