Hydrochloric Acid → cis-2-[(4-Benzoxazol-2-yl)benzyloxy]cyclohexylamine hydrochloride

Participants

Reaction Steps

Cis-1-[4-(benzoxazol-2-yl)benzyloxy]-2-triphenylmethylaminocyclohexane (2.03 g; 3.6 mmol) in 200 ml ethanol is treated with ethanolic HCl to pH 4 and stirred for 24 hrs. at room temperature. The solution is concentrated in vacuo, treated with ether and a white solid which precipitates out is filtered, washed with dry ether and dried in vacuo to obtain cis-2-[(4-benzoxazol-2-yl)benzyloxy]cyclohexylamine hydrochloride (m.p. 280°-281° C. dec).

Provenance & Evidence