反应详情

Cis-1-[4-(benzoxazol-2-yl)benzyloxy]-2-triphenylmethylaminocyclohexane (2.03 g; 3.6 mmol) in 200 ml ethanol is treated with ethanolic HCl to pH 4 and stirred for 24 hrs. at room temperature. The solution is concentrated in vacuo, treated with ether and a white solid which precipitates out is filtered, washed with dry ether and dried in vacuo to obtain cis-2-[(4-benzoxazol-2-yl)benzyloxy]cyclohexylamine hydrochloride (m.p. 280°-281° C. dec).

1. customat room temperature
2. concentrationThe solution is concentrated in vacuo
3. additiontreated with ether
4. customa white solid which precipitates out
5. filtrationis filtered
6. washwashed with dry ether
7. customdried in vacuo