反应详情

2-Mercaptobenzoxazole (4.79 g) was added to a solution of 1,1-difluorobut-1-en-4-yl 4-methylbenzenesulphonate (6.4 g) in acetone (200 cm3) containing potassium carbonate (5.06 g). The mixture was heated to reflux overnight (17 hr) and gc used to confirm that the 1,1-difluorobut-1-en-4-yl 4-methylbenzenesulphonate had been consumed and the product had formed. The reaction mass was allowed to cool and was filtered through a plug of High-Flo filter aid to remove insoluble inorganic material. The solid material was washed with ethyl acetate and the combined organic portions evaporated under reduced pressure to give 7.1 g of a brown oily residue. This material was fractionated by eluting through a bed of silica using hexane/ethyl acetate (40:1 by volume) as solvent to give the required product as a colourless oil (5.4 g, 92% based on the sulphonate); M+ =241;

1. temperatureThe mixture was heated
2. temperatureto reflux overnight (17 hr)
3. customhad been consumed
4. customthe product had formed
5. temperatureto cool
6. filtrationwas filtered through a plug of High-Flo
7. filtrationfilter aid
8. customto remove insoluble inorganic material
9. washThe solid material was washed with ethyl acetate
10. customthe combined organic portions evaporated under reduced pressure