Ethenesulfonyl chloride, 2-phenyl- → HCID 53785241, compound

HRID 2399868Notes

Reaction equation

HRID 2399868 reaction equation
[CH3:1][C:2]([O:5][C:6](=[O:17])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)([CH3:4])[CH3:3].[CH:18]([S:26](Cl)(=[O:28])=[O:27])=[CH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:4][C:2]([CH3:1])([O:5][C:6]([NH:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][S:26]([CH:18]=[CH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:28])=[O:27])=[CH:14][CH:15]=1)=[O:17])[CH3:3]

Participants

3

Reactant 2

HCID 107500Ethenesulfonyl chloride, 2-phenyl-HCID 382207Tert-butyl 4-aminophenethylcarbamate

Product 1

HCID 53785241HCID 53785241, compound

Procedure

In a manner analogous to that of Example 5, the title compound was prepared from the Boc amine from Example 4 and β-styrenesulfonyl chloride: 1H NMR (400 MHz, CDCl3) δ7.47 (d, 1H, J =15.4 Hz), 7.42-7.33 (m, 5H), 7.11 (s, 4H), 6.77 (d, 1H, J=15.4 Hz), 6.56 (br s, 1H), 4.48 (br s, 1H), 4.10 (br m, 2H), 2.72 (t, 2H, J=7.1 Hz), 1.39 (s, 9H).

Sources & evidence

ORD record
ord-83dcd4f8df70461ab07ce5e9712c5b4e
Source dataset
uspto-grants-1995_09
Patent number
US05451677

Reaction notes

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