Tert-butyl 4-aminophenethylcarbamate → HCID 19385028, compound

HRID 2399871Notes

Reaction equation

HRID 2399871 reaction equation
[CH3:1][C:2]([O:5][C:6](=[O:17])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=1)([CH3:4])[CH3:3].[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]1[S:28][C:27]([S:29](Cl)(=[O:31])=[O:30])=[CH:26][CH:25]=1>>[CH3:4][C:2]([CH3:1])([O:5][C:6]([NH:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][S:29]([C:27]2[S:28][C:24]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=3)=[CH:25][CH:26]=2)(=[O:30])=[O:31])=[CH:14][CH:15]=1)=[O:17])[CH3:3]

Participants

3

Reactant 2

HCID 382207Tert-butyl 4-aminophenethylcarbamateHCID 27372315-(2-Pyridyl)thiophene-2-sulfonyl chloride

Product 1

HCID 19385028HCID 19385028, compound

Procedure

In a manner analogous to that of Example 5, the title compound was prepared from the Boc amine from Example 4 and 5-(pyridin-2-yl)-2-thiophenesulfonyl chloride: 1H NMR (400 MHz, CD3OD) 8.48 (d, 1, H, J=5.2 Hz), 7.81 (m, 2H), 7.54 (d, 1H, J=4.1 Hz), 7.41 (m, 1H), 7.30 (m, 1H), 7.11 (s, 4H), 3.18 (t, 2H, J=7.1 Hz), 2.67 (t, 2H, J=7.1 Hz), 1.38 (s, 9H). FAB MS m/z 460 (M+1).

Sources & evidence

ORD record
ord-5fbf36d94aac4b42a8cab09d419df3ce
Source dataset
uspto-grants-1995_09
Patent number
US05451677

Reaction notes

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