Hydrochloric Acid → 5440-22-2

HRID 2399923Notes

Reaction equation

HRID 2399923 reaction equation
C([NH:4][CH:5]([CH:9]([CH3:11])[CH3:10])[C:6](=[O:8])[CH3:7])(=O)C.[ClH:12]>C(O)C>[ClH:12].[O:8]=[C:6]([CH:5]([NH2:4])[CH:9]([CH3:11])[CH3:10])[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12344670HCID 12344670, compound

Product 1

HCID 149026415440-22-2Yield 63%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-acetyl-2-keto-3-amino-4-methylpentane (6.33 g, 40.3 mmol) and 6]hydrochloric acid (65 ml) was heated at reflux overnight. The reaction mixture was cooled to room temperature, ethanol (100 ml) was added and the mixture concentrated under reduced pressure. The mixture was triturated with ether to give a precipitate which was collected by filtration. Crystallisation from acetone gave 2-keto-3-amino-4-methylpentane hydrochloride (2.9 g, 63%) as a white crystalline solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationthe mixture concentrated under reduced pressure
  4. customThe mixture was triturated with ether
  5. customto give a precipitate which
  6. filtrationwas collected by filtration
  7. customCrystallisation from acetone

Sources & evidence

ORD record
ord-b89e151a5fcf424587277b8e8b155843
Source dataset
uspto-grants-1995_09
Patent number
US05451676

Reaction notes

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