Hydrochloric Acid → HCID 67746333, compound

HRID 2400009Notes

Reaction equation

HRID 2400009 reaction equation
[ClH:1].C(O[N:7]1[CH2:15][CH:14]2[CH:9]([C:10]([F:29])([F:28])[CH2:11][CH2:12][C:13]2([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]1=C=O)(C)(C)C>O1CCOCC1>[ClH:1].[C:22]1([C:13]2([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:12][CH2:11][C:10]([F:29])([F:28])[CH:9]3[CH:14]2[CH2:15][NH:7][CH2:8]3)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86749005HCID 86749005, compound

Product 1

HCID 67746333HCID 67746333, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

20 cm3 of dioxane and 20 cm3 of 6.3N hydrochloric acid are added to 1.8 g of (3aRS,7aRS)-2-tert-butyloxy-carbonyl-4,4-diphenyl-7,7-difluoroperhydroisoindole. After stirring for 20 hours at room temperature, the white suspension obtained is concentrated to dryness at 40° C. under reduced pressure (2.7 kPa). The residue is washed with diisopropyl oxide, the solid obtained is drained and then dried. 1.51 g of (3aRS,7aRS)-4,4-diphenyl-7,7-difluoroperhydroisoindole hydrochloride are obtained in the form of a white solid.

Workup

  1. customthe white suspension obtained
  2. concentrationis concentrated to dryness at 40° C. under reduced pressure (2.7 kPa)
  3. washThe residue is washed with diisopropyl oxide
  4. customthe solid obtained
  5. customdried

Sources & evidence

ORD record
ord-afcad7f6ed0644be8363d274e5fc4e78
Source dataset
uspto-grants-1995_09
Patent number
US05451601

Reaction notes

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