Ethylamine → Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate

HRID 2400057Notes

Reaction equation

HRID 2400057 reaction equation
[O:1]1[C:3]2([CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4]2)[CH2:2]1.[CH2:13]([NH2:15])[CH3:14]>>[CH2:13]([NH:15][CH2:2][C:3]1([OH:1])[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4]1)[CH3:14]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 14578448Ethyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate

Product 1

HCID 14578449Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate

Procedure

8 g (46.7 mmol) of ethyl 5-aza-1-oxaspiro[2,4]heptane-5-carboxylate are added dropwise to 50 ml of ethylamine solution (50% in water) and the mixture is stirred overnight at room temperature. It is concentrated and the residue is distilled.

Workup

  1. concentrationIt is concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-e9b79ac43c3a4346a70bd8366243fa68
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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