HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Ethyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate | HCID 14578448 | — |
| Product | Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate | HCID 14578449 | — |
Reaction Steps
8 g (46.7 mmol) of ethyl 5-aza-1-oxaspiro[2,4]heptane-5-carboxylate are added dropwise to 50 ml of ethylamine solution (50% in water) and the mixture is stirred overnight at room temperature. It is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05453422 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-e9b79ac43c3a4346a70bd8366243fa68 |
| Source note | uspto-grants-1995_09 |