Ethylamine → 1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine

HRID 2400060Notes

Reaction equation

HRID 2400060 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]2([O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]([NH2:17])[CH3:16]>>[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]([CH2:11][NH:17][CH2:15][CH3:16])([OH:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 111948055-Benzyl-1-oxa-5-azaspiro[2.4]heptane

Product 1

HCID 145784521-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine

Procedure

10.2 g (53.9 mmol) of 5-benzyl-5-aza-1-oxaspiro-[2,4]heptane are added dropwise to 60 ml of aqueous ethylamine solution (50%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.

Workup

  1. concentrationThe batch is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-5ad06185ef514c8b814da9835bd1dce6
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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